| ADR Ontology |
| ADR Term |
Hepatic failure |
| ADR ID |
BADD_A02001 |
| ADR Hierarchy |
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| Description |
A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, alkaline phosphatase, aminotransferase, and/or prolongation of prothrombin time (INR.) Drug-induced liever injury (DILI) as defined by Hy's Law. [CTCAE] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed) [MeSH] |
| MedDRA Code |
10019663 |
| MeSH ID |
D017093; D017093; D017093; D017093; D048550
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Synonym |
| Failure liver | Hepatic failure | Liver failure | Hepatic insufficiency | Hepatobiliary insufficiency | Hepatic decompensation | Liver Failure | Hepatic Failure |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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